UPSC 2021ScienceModerate

In the context of hereditary diseases, consider the following statements : 1. Passing on mitochondrial diseases from parent to child can be prevented by mitochondrial replacement therapy either before or after in vitro fertilization of egg. 2. A child inherits mitochondrial diseases entirely from mother and not from father. Which of the statements given above is/are correct?

A
1 only
B
2 only
C
Both 1 and 2
Correct Answer
D
Neither 1 nor 2

Explanation

Statement 1 is correct as Mitochondrial Replacement Therapy (MRT) can be performed via Maternal Spindle Transfer (before fertilization) or Pronuclear Transfer (after fertilization), while Statement 2 is correct because mitochondrial DNA is inherited exclusively from the mother's egg. Option (a) is a common distractor for those who mistakenly believe MRT is limited to a single stage of the IVF process or that paternal mitochondria contribute to the offspring's genome. The core concept tested is the matrilineal inheritance of organelles and the application of advanced reproductive biotechnologies to prevent hereditary diseases.

Biotechnology & Human HealthMitochondrial Diseases & Reproductive Technologiesmitochondrial diseasesmitochondrial replacement therapyin vitro fertilization (IVF)maternal inheritancepaternal inheritance

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